The phosphate salt of codeine occurs as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and a bit soluble in alcohol. The molecular bodyweight is 406.37. Its molecular components is C18H21NO3•H3PO4 • ½ H2O, and it has the subsequent chemical framework.
The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric patients fewer than 6 decades of age. Concomitant administration of promethazine merchandise with other respiratory depressants has an association with respiratory melancholy, and sometimes Demise, in pediatric patients. The association does in a roundabout way relate to individualized bodyweight-centered dosing, which might normally allow safe administration.
Pediatric people need to be supervised to avoid possible hurt in bike riding or in other dangerous functions.
Concomitant administration of promethazine goods with other respiratory depressants has an association with respiratory depression, and in some cases death, in pediatric individuals.
Promethazine HCl Oral Answer really should be utilized cautiously in people with cardiovascular disease or with impairment of liver function.
For prescriptions where a measuring system isn't provided, a pharmacist can offer an proper calibrated measuring device and can provide instructions for measuring the proper dose.
As a result of very similar pharmacologic Attributes, it is sensible to assume very similar hazard with concomitant usage of opioid cough remedies and benzodiazepines, other CNS depressants, or Alcoholic beverages.
Promethazine HCl Oral Option ought to be used cautiously in folks with cardiovascular disease or with impairment of liver function.
Promethazine HCl Oral Alternative could lower seizure threshold. It should be used with caution in folks with seizure Ailments or in folks who're working with concomitant prescription drugs, like narcotics or nearby anesthetics, which may also affect seizure threshold.
Outcomes to the Cardiovascular System Codeine provides peripheral vasodilation which may lead to orthostatic hypotension or syncope. Manifestations of histamine launch and/or peripheral vasodilation could include pruritus, flushing, purple eyes and perspiring and/or orthostatic hypotension.
Propulsive peristaltic waves while in the colon are diminished, though tone might be improved to more info the point of spasm leading to constipation. Other opioid-induced outcomes may well involve a discount in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.
Promethazine HCl Oral Resolution is contraindicated in comatose states, and in persons acknowledged to get hypersensitive or to possess had an idiosyncratic response to Promethazine or to other phenothiazines.
In animal reproduction studies, codeine administered because of the oral route to Expecting rats in the duration of organogenesis greater resorptions and lowered fetal weights at a dose around 25 instances the utmost advised human dose (MRHD) while in the presence of maternal toxicity (see Knowledge).
Promethazine Signals and indications of overdosage with promethazine range between delicate depression from the central anxious process and cardiovascular technique to profound hypotension, respiratory melancholy, unconsciousness and unexpected death.